PPIPT00256

Target Protein Information
Protein_Name Genome polyprotein
Protein_Sequence MRCIGISNRDFVEGVSGGSWVDIVLEHGSCVTTMAKNKPTLDFELIKTEAKQPATLRKYCIEAKLTNTTTESRCPTQGEPSLNEEQDKRFVCKHSMVDRGWGNGCGLFGKGGIVTCAMFTCQKNMEGKIVQPENLEYTIVVTPHSGEEHAVGNDTGKHGKEIKITPQSSITEAELTGYGTVTMDCSPRTGLDFNEMVLLQMENKAWLVHRQWFLDLPLPWLPGADTQGSKLDQKETLVTFKNPHAKKQDVVVLGSQEGAMHTALTGATEIQMSSGNLLFTGHLKCRLRMDKLQLKGMSYSMCTGKFKVVEEIAETQHGTIVIRVQYEGDGSPCKIPLEIMDLDNRHVLGRLITVNPIVTEKDSPVNVEAEPPLGDSYIIIGVEPGQLKLNWFKKGSSIGQMFETTMIRAKRMAILGDTAWDFRSLGGVFTSIGKALHQVFGAIYGAAFSGVSWTMKILIGVIITWIGMNSRSTSLSVSLVLVGIVTLYLGVMVQA
Organism_Source Dengue virus type 2 (isolate Malaysia M2)
Functional_Classification Viral polyprotein
Cellular_Localization Extracellular
Gene_Names None
UniProt_ID P14338
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name HDIII3CL2
Peptide_Sequence DWFKHEWCKKK
Peptide_Length 11
Peptide_SMILES NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(=O)O
Chemical_Modification None
Cyclization_Method Side chain cyclization; C1<->C18; disulfide bond
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1534.80
Aliphatic_Index 0.00000
Aromaticity 0.27273
Average_Rotatable_Bonds 4.63636
Charge_at_pH_7 2.02796
Isoelectric_point 9.51525
Number_of_Hydrogen_Bond_Acceptors 20
Number_of_Hydrogen_Bond_Donors 22
Topological_Polar_Surface_Area 593.26000
X_logP_energy -1.31190
Interaction Information
Affinity IC50=20 mM
Affinity_Assay plaque formation assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Patent
Title BETA-HAIRPIN PEPTIDES HAVING ANTI-VIRAL PROPERTIES AGAINST THE DENGUE VIRUS
Release_Year 2017
Patent_ID EP3115056A2