PPIPT00258

Target Protein Information
Protein_Name Dihydropyrimidinase-related protein 2
Protein_Sequence MSYQGKKNIPRITSDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGTSLLAAFDQWREWADSKSCCDYSLHVDITEWHKGIQEEMEALVKDHGVNSFLVYMAFKDRFQLTDSQIYEVLSVIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRSITIANQTNCPLYVTKVMSKSAAEVIAQARKKGTVVYGEPITASLGTDGSHYWSKNWAKAAAFVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAVGKDNFTLIPEGTNGTEERMSVIWDKAVVTGKMDENQFVAVTSTNAAKVFNLYPRKGRISVGSDADLVIWDPDSVKTISAKTHNSALEYNIFEGMECRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPRKPFPDFVYKRIKARSRLAELRGVPRGLYDGPVCEVSVTPKTVTPASSAKTSPAKQQAPPVRNLHQSGFSLSGAQIDDNIPRRTTQRIVAPPGGRANITSLG
Organism_Source Rattus norvegicus
Functional_Classification Cytoskeletal regulator
Cellular_Localization Cytoplasm
Gene_Names Dpysl2
UniProt_ID P47942
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Ct-dis peptide (CaV1.2 distal C-terminus)
Peptide_Sequence NSSFPSIHCSSWSEE
Peptide_Length 15
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1696.77
Aliphatic_Index 26.00000
Aromaticity 0.13333
Average_Rotatable_Bonds 3.40000
Charge_at_pH_7 -1.96953
Isoelectric_point 4.25423
Number_of_Hydrogen_Bond_Acceptors 27
Number_of_Hydrogen_Bond_Donors 27
Topological_Polar_Surface_Area 745.47000
X_logP_energy -10.84110
Interaction Information
Affinity KD=0.64 uM
Affinity_Assay MicroScale Thermophoresis
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Patent
Title PEPTIDE CONJUGATES FOR TREATING PAIN
Release_Year 2015
Patent_ID US20150151000A1