PPIPT00323
Target Protein Information
| Protein_Name | Histone H3.3 |
|---|---|
| Protein_Sequence | MARTKQTARKSTGGKAPRKQLATKAARKSAPSTGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSAAIGALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA |
| Organism_Source | Homo sapiens |
| Functional_Classification | Histone variant |
| Cellular_Localization | Nucleus |
| Gene_Names | H3-3A |
| UniProt_ID | P84243 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | H3.3.Non-M (26-35) |
|---|---|
| Peptide_Sequence | RKSAPSTGGV |
| Peptide_Length | 10 |
| Peptide_SMILES | CC(C)[C@H](NC(=O)CNC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCNC(=N)N)[C@@H](C)O)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 959.07 |
|---|---|
| Aliphatic_Index | 39.00000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.00000 |
| Charge_at_pH_7 | 1.99769 |
| Isoelectric_point | 11.65178 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 16 |
| Number_of_Hydrogen_Bond_Donors | 17 |
| Topological_Polar_Surface_Area | 465.04000 |
| X_logP_energy | -8.03593 |
Interaction Information
| Affinity | IC50=22651 nM |
|---|---|
| Affinity_Assay | Enzyme Inhibition Kinetics |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | H3.3 CTL PEPTIDES AND USES THEREOF |
| Release_Year | 2020 |
| Patent_ID | US20200009236A1 |