PPIPT00324
Target Protein Information
| Protein_Name | F2R like thrombin or trypsin receptor 3 |
|---|---|
| Protein_Sequence | MWEPLLWLLVLGLGLAGSTSTPSVYDEDDGEWPGPWASSEAARTPQQVAPRSFPGQASANDSDVLELPDSLQVLLLGWAPTRLVPALYALALAVGLPANALALWVLARHGPRLPATALLMNLAAADLLLGLALPPRLVYHLRGQRWPLGEAACRVSTATLYGHMYGAALLLAAISLDRYLALVHPLRARALRGRRLATGLCMSAWLGAATLAAPLALGRQTFRLAGSGHLLCHDVLPLATQTAFWRPAFLCLAALGCFLPLLLMALCHGVTLCVLAAGSRRHSHALRLTALVLASAVAFFVPSNVLLLLHYTDPSPGAGGELYGAYLPSLALSTLNSCVDPFLYYYASPEFRDKVRAQLRCWLPRTTATSQGSQDVGSAGT |
| Organism_Source | Cavia porcellus |
| Functional_Classification | Proteinase-activated receptor 4 |
| Cellular_Localization | Plasma membrane |
| Gene_Names | F2RL3 |
| UniProt_ID | A0A286XGK0 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Guinea pig PAR-4 activating peptide |
|---|---|
| Peptide_Sequence | SFPGQA |
| Peptide_Length | 6 |
| Peptide_SMILES | C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 605.65 |
|---|---|
| Aliphatic_Index | 16.66667 |
| Aromaticity | 0.16667 |
| Average_Rotatable_Bonds | 2.66667 |
| Charge_at_pH_7 | -0.00202 |
| Isoelectric_point | 6.10000 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 9 |
| Number_of_Hydrogen_Bond_Donors | 8 |
| Topological_Polar_Surface_Area | 263.35000 |
| X_logP_energy | -3.51970 |
Interaction Information
| Affinity | EC50=174 uM |
|---|---|
| Affinity_Assay | platelet aggregation assay |
| PDB_ID | None |
| Type | Agonist |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | GUINEA PIG PROTEINASE-ACTIVATED RECEPTOR 4 AND ITS ACTIVATING PEPTIDE |
| Release_Year | 2006 |
| Patent_ID | US20060141451A1 |