PPIPT00337
Target Protein Information
| Protein_Name | Programmed cell death 1 ligand 1 |
|---|---|
| Protein_Sequence | MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET |
| Organism_Source | Homo sapiens |
| Functional_Classification | Immune checkpoint ligand |
| Cellular_Localization | Plasma membrane |
| Gene_Names | CD274 |
| UniProt_ID | Q9NZQ7 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | PPLC |
|---|---|
| Peptide_Sequence | VSVSHFQKVWVV |
| Peptide_Length | 12 |
| Peptide_SMILES | CC(C)[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@H](C(=O)O)C(C)C)C(C)C)C(C)C)C(C)C |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1414.67 |
|---|---|
| Aliphatic_Index | 120.83333 |
| Aromaticity | 0.16667 |
| Average_Rotatable_Bonds | 3.58333 |
| Charge_at_pH_7 | 1.08860 |
| Isoelectric_point | 9.70200 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 18 |
| Number_of_Hydrogen_Bond_Donors | 19 |
| Topological_Polar_Surface_Area | 537.46000 |
| X_logP_energy | -2.67730 |
Interaction Information
| Affinity | KD=0.75 uM |
|---|---|
| Affinity_Assay | ELISA |
| PDB_ID | None |
| Type | Antagonist |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | PEPTIDE HAVING HIGH AFFINITY FOR PD-L1 PROTEIN AND USE THEREOF |
| Release_Year | 2021 |
| Patent_ID | US20210230286A1 |