PPIPT00348
Target Protein Information
| Protein_Name | Beta-2-glycoprotein 1 |
|---|---|
| Protein_Sequence | MISPVLILFSSFLCHVAIAGRTCPKPDDLPFSTVVPLKTFYEPGEEITYSCKPGYVSRGGMRKFICPLTGLWPINTLKCTPRVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWTKLPECREVKCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGYSLDGPEEIECTKLGNWSAMPSCKASCKVPVKKATVVYQGERVKIQEKFKNGMLHGDKVSFFCKNKEKKCSYTEDAQCIDGTIEVPKCFKEHSSLAFWKTDASDVKPC |
| Organism_Source | Homo sapiens |
| Functional_Classification | Plasma glycoprotein |
| Cellular_Localization | Extracellular |
| Gene_Names | APOH |
| UniProt_ID | P02749 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | CB2*-F |
|---|---|
| Peptide_Sequence | GPCILLARDRCG |
| Peptide_Length | 12 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](CS)NC(=O)[C@@H]1CCCN1C(=O)CN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CS)C(=O)NCC(=O)O |
| Chemical_Modification | FITC=N-terminal |
| Cyclization_Method | Side chain-side chain cyclization; C1<->C12; disulfide bond |
| Linear/Cyclic | Linear |
| N-terminal_Modification | FITC |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1273.53 |
|---|---|
| Aliphatic_Index | 105.83333 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.33333 |
| Charge_at_pH_7 | 0.87447 |
| Isoelectric_point | 8.23140 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 18 |
| Number_of_Hydrogen_Bond_Donors | 21 |
| Topological_Polar_Surface_Area | 535.73000 |
| X_logP_energy | -5.48086 |
Interaction Information
| Affinity | KD=256 nM |
|---|---|
| Affinity_Assay | Fluorescence Polarization |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | APL IMMUNOREACTIVE PEPTIDES, CONJUGATES THEREOF AND METHODS OF TREATMENT FOR APL ANTIBODY-MEDIATED PATHOLOGIES |
| Release_Year | 2004 |
| Patent_ID | US20040009904A1 |