PPIPT00385

Target Protein Information
Protein_Name Neutrophil cytosol factor 1
Protein_Sequence MGDTFIRHIALLGFEKRFVPSQHYVYMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPIEAGAINPENRIIPHLPAPKWFDGQRAAENRQGTLTEYCSTLMSLPTKISRCPHLLDFFKVRPDDLKLPTDNQTKKPETYLMPKDGKSTATDITGPIILQTYRAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETEDPEPNYAGEPYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQKSGQDVSQAQRQIKRGAPPRRSSIRNAHSIHQRSRKRLSQDAYRRNSVRFLQQRRRQARPGPQSPGSPLEEERQTQRSKPQPAVPPRPSADLILNRCSESTKRKLASAV
Organism_Source Homo sapiens
Functional_Classification NADPH oxidase cytosolic subunit
Cellular_Localization Cytoplasm
Gene_Names NCF1
UniProt_ID P14598
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name p22-phox proline-rich peptide
Peptide_Sequence PPSNPPPRPP
Peptide_Length 10
Peptide_SMILES N=C(N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Cyclic
N-terminal_Modification Europium cryptate
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1055.20
Aliphatic_Index 0.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 2.00000
Charge_at_pH_7 0.99798
Isoelectric_point 10.55000
Number_of_Hydrogen_Bond_Acceptors 14
Number_of_Hydrogen_Bond_Donors 10
Topological_Polar_Surface_Area 383.71000
X_logP_energy -4.64563
Interaction Information
Affinity IC50=5.8 nM
Affinity_Assay Fluorescence Polarization
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Patent
Title Method for the screening of compounds that inhibit the interaction between a proline-rich peptide and an SH3 domain comprising peptide
Release_Year 2003
Patent_ID EP1281962A1