PPIPT00387

Target Protein Information
Protein_Name Histidine-rich protein 2
Protein_Sequence CSKNAKGLNLNKRLLHETQAHVDDAHHAHHVADAHHAHHVADAHHAHHAADAHHAHHVADAHHAHHVADAHHAHHAADAHHAHHAADAHHAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAAYAHHAHHASDAHHAADAHHAAYAHHAHHAADAHHAADAHHATDAHHAADAHHAADAHHATDAHHAADAHHAADAHHAADAHHAAAHHATDAHHAAAHHATDAHHATDAHHAAAHHEAATHCLRH
Organism_Source Plasmodium falciparum
Functional_Classification Histidine-rich protein 2
Cellular_Localization Cytoplasm
Gene_Names HRP2
UniProt_ID A0A2H4V100
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name cy(FVNSTQT)-TZ4
Peptide_Sequence FVNSTQT
Peptide_Length 7
Peptide_SMILES CC(C)[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method Main chain-main chain cyclization; F1<->T7; other bonds
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 795.85
Aliphatic_Index 41.42857
Aromaticity 0.14286
Average_Rotatable_Bonds 3.42857
Charge_at_pH_7 -0.00202
Isoelectric_point 6.10000
Number_of_Hydrogen_Bond_Acceptors 13
Number_of_Hydrogen_Bond_Donors 13
Topological_Polar_Surface_Area 384.79000
X_logP_energy -5.89940
Interaction Information
Affinity EC50=20 nM
Affinity_Assay ELISA
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Patent
Title CYCLIC PEPTIDES AS PROTEIN TARGETING AGENTS
Release_Year 2015
Patent_ID US20150078999A1