PPIPT00415

Target Protein Information
Protein_Name HLA class II histocompatibility antigen, DRB1 beta chain
Protein_Sequence MVCLKLPGGSCMTALTVTLMVLSSPLALSGDTRPRFLWQPKRECHFFNGTERVRFLDRYFYNQEESVRFDSDVGEFRAVTELGRPDAEYWNSQKDILEQARAAVDTYCRHNYGVVESFTVQRRVQPKVTVYPSKTQPLQHHNLLVCSVSGFYPGSIEVRWFLNGQEEKAGMVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRARSESAQSKMLSGVGGFVLGLLFLGAGLFIYFRNQKGHSGLQPTGFLS
Organism_Source Homo sapiens
Functional_Classification MHC class II molecule
Cellular_Localization Plasma membrane
Gene_Names HLA-DRB1
UniProt_ID P01911
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name HA306-318
Peptide_Sequence PKYVKQNTLKLAT
Peptide_Length 13
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1)C(C)C)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)O)[C@@H](C)O
Chemical_Modification N-terminal biotin via 2-6-aminohexanoic acid linker
Cyclization_Method None
Linear/Cyclic Cyclic
N-terminal_Modification biotinylated
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1503.81
Aliphatic_Index 90.00000
Aromaticity 0.07692
Average_Rotatable_Bonds 3.92308
Charge_at_pH_7 2.99625
Isoelectric_point 10.64292
Number_of_Hydrogen_Bond_Acceptors 22
Number_of_Hydrogen_Bond_Donors 22
Topological_Polar_Surface_Area 623.46000
X_logP_energy -5.35350
Interaction Information
Affinity KD=6.37 uM
Affinity_Assay flow cytometry
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Patent
Title UNIVERSAL PEPTIDE-BINDING SCAFFOLDS AND PROTEIN CHIPS
Release_Year 2005
Patent_ID US20050191706A1