PPIPT00470

Target Protein Information
Protein_Name Intermediate conductance calcium-activated potassium channel protein 4
Protein_Sequence MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCSWALYLFLVKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALTGRQAAQIVLELVVCGLHPAPVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYRSIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLSDTLWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHNFMMDIQYTKEMKESAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVRLKHRKLREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLPEPSQQSK
Organism_Source Homo sapiens
Functional_Classification Calcium-activated potassium channel
Cellular_Localization Plasma membrane
Gene_Names KCNN4
UniProt_ID O15554
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Vm24
Peptide_Sequence AAASCWGSPECPPKCRAQGCKNGKCMNRKCKCYYC
Peptide_Length 35
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CS)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CS)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CS)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CS)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CS)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](C)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CS)C(=O)O
Chemical_Modification None
Cyclization_Method Side chain cyclization; C6<->C26; disulfide bond; Side chain cyclization; C12<->C31; disulfide bond; Side chain cyclization; C16<->C33; disulfide bond; Side chain cyclization; C21<->C36; disulfide bond
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 3846.56
Aliphatic_Index 11.42857
Aromaticity 0.08571
Average_Rotatable_Bonds 3.51429
Charge_at_pH_7 5.50078
Isoelectric_point 8.78245
Number_of_Hydrogen_Bond_Acceptors 60
Number_of_Hydrogen_Bond_Donors 61
Topological_Polar_Surface_Area 1543.53000
X_logP_energy -19.77676
Interaction Information
Affinity Ki=14 nM
Affinity_Assay whole-cell patch clamp
PDB_ID None
Type Antagonist
Structure
Reference Information
Document_Type Patent
Title VM23 AND VM24, TWO SCORPION PEPTIDES THAT BLOCK HUMAN T LYMPHOCYTE POTASSIUM CHANNELS (SUB-TYPE KV1.3) W/HIGH SELECTIVITY AND DECREASE THE IN VIVO DTH-RESPONSES IN RATS
Release_Year 2011
Patent_ID US20110059064A1