PPIPT00496
Target Protein Information
| Protein_Name | Secreted frizzled-related protein 1 |
|---|---|
| Protein_Sequence | MGIGRSEGGRRGAALGVLLALGAALLAVGSASEYDYVSFQSDIGPYQSGRFYTKPPQCVDIPADLRLCHNVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHAGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPEGDVCIAMTPPNATEASKPQGTTVCPPCDNELKSEAIIEHLCASEFALRMKIKEVKKENGDKKIVPKKKKPLKLGPIKKKDLKKLVLYLKNGADCPCHQLDNLSHHFLIMGRKVKSQYLLTAIHKWDKKNKEFKNFMKKMKNHECPTFQSVFK |
| Organism_Source | Homo sapiens |
| Functional_Classification | Wnt signaling antagonist |
| Cellular_Localization | Extracellular |
| Gene_Names | SFRP1 |
| UniProt_ID | Q8N474 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | A-C2 |
|---|---|
| Peptide_Sequence | QGTLVDGRWLQL |
| Peptide_Length | 12 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](N)CCC(N)=O)[C@@H](C)O)C(C)C)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1385.59 |
|---|---|
| Aliphatic_Index | 121.66667 |
| Aromaticity | 0.08333 |
| Average_Rotatable_Bonds | 3.75000 |
| Charge_at_pH_7 | -0.00157 |
| Isoelectric_point | 6.33872 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 18 |
| Number_of_Hydrogen_Bond_Donors | 21 |
| Topological_Polar_Surface_Area | 604.82000 |
| X_logP_energy | -4.83803 |
Interaction Information
| Affinity | KD=3.9 uM |
|---|---|
| Affinity_Assay | Isothermal Titration Calorimetry |
| PDB_ID | None |
| Type | Antagonist |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | SFRP AND PEPTIDE MOTIFS THAT INTERACT WITH SFRP AND METHODS OF THEIR USE |
| Release_Year | 2008 |
| Patent_ID | US20080145884A1 |