PPIPT00535

Target Protein Information
Protein_Name Immunoglobulin heavy constant gamma 1
Protein_Sequence ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPELQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATVTFFKVKWIFSSVVDLKQTIIPDYRNMIGQGA
Organism_Source Homo sapiens
Functional_Classification IgG heavy chain constant region
Cellular_Localization Extracellular
Gene_Names IGHG1
UniProt_ID P01857
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name GFc-C35-2/16
Peptide_Sequence PDCTYTNGNLVWCTF
Peptide_Length 15
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)O)C(C)C
Chemical_Modification None
Cyclization_Method Side chain-side chain cyclization; C3<->C12; disulfide bond
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1733.93
Aliphatic_Index 45.33333
Aromaticity 0.20000
Average_Rotatable_Bonds 3.26667
Charge_at_pH_7 -1.12637
Isoelectric_point 3.74996
Number_of_Hydrogen_Bond_Acceptors 25
Number_of_Hydrogen_Bond_Donors 26
Topological_Polar_Surface_Area 676.92000
X_logP_energy -6.91380
Interaction Information
Affinity KD=25 mM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Patent
Title IgG-BINDING PEPTIDE AND METHOD FOR DETECTING AND PURIFYING IgG USING SAME
Release_Year 2014
Patent_ID EP2749646A1