PPIPT00546

Target Protein Information
Protein_Name Immunoglobulin heavy constant gamma 1
Protein_Sequence ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPELQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATVTFFKVKWIFSSVVDLKQTIIPDYRNMIGQGA
Organism_Source Homo sapiens
Functional_Classification IgG heavy chain constant region
Cellular_Localization Extracellular
Gene_Names IGHG1
UniProt_ID P01857
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name C35A (D3R,T15S)
Peptide_Sequence GPRCAYHRGELVWCSFH
Peptide_Length 17
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@H](CS)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)CN)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)O)C(C)C
Chemical_Modification None
Cyclization_Method Side chain-side chain cyclization; C4<->C14; disulfide bond
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2018.30
Aliphatic_Index 45.88235
Aromaticity 0.17647
Average_Rotatable_Bonds 3.47059
Charge_at_pH_7 1.05677
Isoelectric_point 8.24540
Number_of_Hydrogen_Bond_Acceptors 27
Number_of_Hydrogen_Bond_Donors 31
Topological_Polar_Surface_Area 794.84000
X_logP_energy -6.26406
Interaction Information
Affinity KD=0.042 mM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Patent
Title IgG-BINDING PEPTIDE AND METHOD FOR DETECTING AND PURIFYING IgG USING SAME
Release_Year 2014
Patent_ID EP2749646A1