PPIPT00564
Target Protein Information
| Protein_Name | Bcl-2-like protein 2 |
|---|---|
| Protein_Sequence | MATPASAPDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQAMRAAGDEFETRFRRTFSDLAAQLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVGQVQEWMVAYLETQLADWIHSSGGWAEFTALYGDGALEEARRLREGNWASVRTVLTGAVALGALVTVGAFFASK |
| Organism_Source | Homo sapiens |
| Functional_Classification | Bcl-2 family anti-apoptotic protein |
| Cellular_Localization | Mitochondria |
| Gene_Names | BCL2L2 |
| UniProt_ID | Q92843 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | B |
|---|---|
| Peptide_Sequence | IAQELRRIGDEF |
| Peptide_Length | 12 |
| Peptide_SMILES | CC[C@H](C)[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC |
| Chemical_Modification | None |
| Cyclization_Method | Side chain cyclization; E4<->E11; amide bond |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Acetyl |
| C-terminal_Modification | Amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1446.63 |
|---|---|
| Aliphatic_Index | 105.83333 |
| Aromaticity | 0.08333 |
| Average_Rotatable_Bonds | 4.16667 |
| Charge_at_pH_7 | -0.99803 |
| Isoelectric_point | 4.42641 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 19 |
| Number_of_Hydrogen_Bond_Donors | 23 |
| Topological_Polar_Surface_Area | 662.21000 |
| X_logP_energy | -5.24026 |
Interaction Information
| Affinity | IC50=6.5 nM |
|---|---|
| Affinity_Assay | AlphaScreen |
| PDB_ID | None |
| Type | Antagonist |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | Peptides and therapeutic uses thereof |
| Release_Year | 2007 |
| Patent_ID | US20070032417A1 |