PPIPT00573

Target Protein Information
Protein_Name Chemerin-like receptor 2
Protein_Sequence MEDLEETLFEEFENYSYDLDYYSLESDLEEKVQLGVVHWVSLVLYCLAFVLGIPGNAIVIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHDPDLTLIRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRHFWTILVVVVAFVVCWTPYHLFSIWELTIHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARFRSSVAEILKYTLWEVSCSGTVSEQLRNSETKNLCLLETAQ
Organism_Source Homo sapiens
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names CMKLR2
UniProt_ID P46091
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Ala8-Humanin
Peptide_Sequence MAPRGFSALLLLTSEDLPVKRRA
Peptide_Length 23
Peptide_SMILES CSCC[C@H](N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)O)C(C)C)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2542.04
Aliphatic_Index 110.43478
Aromaticity 0.04348
Average_Rotatable_Bonds 3.60870
Charge_at_pH_7 1.99990
Isoelectric_point 11.37806
Number_of_Hydrogen_Bond_Acceptors 34
Number_of_Hydrogen_Bond_Donors 37
Topological_Polar_Surface_Area 1032.95000
X_logP_energy -8.72659
Interaction Information
Affinity EC50=55.6 nM
Affinity_Assay beta-arrestin2 recruitment assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Patent
Title NATURAL PEPTIDE AND DERIVATIVES AS MODULATORS OF GPCR GPR1 AND USES THEREOF
Release_Year 2012
Patent_ID US20120202221A1