PPIPT00597

Target Protein Information
Protein_Name T cell receptor alpha chain constant
Protein_Sequence IQNPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKTVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDTFFPSPESSCDVKLVEKSFETDTNLNFQNLSVIGFRILLLKVAGFNLLMTLRLWSS
Organism_Source Homo sapiens
Functional_Classification T-cell receptor constant region
Cellular_Localization Plasma membrane
Gene_Names TRAC
UniProt_ID P01848
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name ISU
Peptide_Sequence LQARILAVERYLKDQQL
Peptide_Length 17
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2057.42
Aliphatic_Index 143.52941
Aromaticity 0.05882
Average_Rotatable_Bonds 4.23529
Charge_at_pH_7 0.99905
Isoelectric_point 9.29642
Number_of_Hydrogen_Bond_Acceptors 27
Number_of_Hydrogen_Bond_Donors 31
Topological_Polar_Surface_Area 902.84000
X_logP_energy -6.17876
Interaction Information
Affinity Ki=15 uM
Affinity_Assay cell proliferation assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Patent
Title PEPTIDES DERIVED FROM HIV GP41 FOR TREATING T-CELL MEDIATED PATHOLOGIES
Release_Year 2015
Patent_ID US20150175666A1