PPIPT00599

Target Protein Information
Protein_Name T cell receptor alpha chain constant
Protein_Sequence IQNPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKTVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDTFFPSPESSCDVKLVEKSFETDTNLNFQNLSVIGFRILLLKVAGFNLLMTLRLWSS
Organism_Source Homo sapiens
Functional_Classification T-cell receptor constant region
Cellular_Localization Plasma membrane
Gene_Names TRAC
UniProt_ID P01848
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Pep8
Peptide_Sequence WNASWSNKSLEQIWNHT
Peptide_Length 17
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2101.26
Aliphatic_Index 51.76471
Aromaticity 0.17647
Average_Rotatable_Bonds 3.82353
Charge_at_pH_7 0.09037
Isoelectric_point 7.54973
Number_of_Hydrogen_Bond_Acceptors 29
Number_of_Hydrogen_Bond_Donors 32
Topological_Polar_Surface_Area 921.57000
X_logP_energy -9.35180
Interaction Information
Affinity IC50=15 uM
Affinity_Assay cell proliferation assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Patent
Title PEPTIDES DERIVED FROM HIV GP41 FOR TREATING T-CELL MEDIATED PATHOLOGIES
Release_Year 2015
Patent_ID US20150175666A1