PPIPT00601

Target Protein Information
Protein_Name T cell receptor alpha chain constant
Protein_Sequence IQNPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKTVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDTFFPSPESSCDVKLVEKSFETDTNLNFQNLSVIGFRILLLKVAGFNLLMTLRLWSS
Organism_Source Homo sapiens
Functional_Classification T-cell receptor constant region
Cellular_Localization Plasma membrane
Gene_Names TRAC
UniProt_ID P01848
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name D-Pep6
Peptide_Sequence SNKSLEQIWNHTTWMEWD
Peptide_Length 18
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)O)[C@@H](C)O)[C@@H](C)O
Chemical_Modification S1=D-Ser; D18=D-Asp
Cyclization_Method None
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2305.51
Aliphatic_Index 43.33333
Aromaticity 0.16667
Average_Rotatable_Bonds 4.05556
Charge_at_pH_7 -1.90740
Isoelectric_point 4.42146
Number_of_Hydrogen_Bond_Acceptors 32
Number_of_Hydrogen_Bond_Donors 34
Topological_Polar_Surface_Area 982.18000
X_logP_energy -8.28120
Interaction Information
Affinity IC50=0.55 uM
Affinity_Assay cell proliferation assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Patent
Title PEPTIDES DERIVED FROM HIV GP41 FOR TREATING T-CELL MEDIATED PATHOLOGIES
Release_Year 2015
Patent_ID US20150175666A1