PPIPT00612

Target Protein Information
Protein_Name Minor capsid protein L2
Protein_Sequence MRHKRSTRRKRASATQLYQTCKAAGTCPPDVIPKVERTTIADQILKFGSLGVFFGGLGIGTGSGTGGRTGYVPLSTRPPTASAPTSTIRPPVSVDTVGPLDSSIVSMIEETSFIESGAPAPSIPTASGFDVATSADNTPAIINVSSIGESSVQSVTTHLNPTFTEPSVLRPFSSSEASGHLIFSTPTISTHSYEDIPMDTFIVSTTSDNVTSSTPIPRPRPTARLGLYSKGTQQVKVVDPAFLTSPRRLITFDNPAFQPTEPDETLYFQHQDISPAPDPDFLDIVALHRPALTSRKGTIRFSRLGSKATMKTRSGKQIGARVHYYQDLSPIVPADSIELQPLSRPVSSASHSINDGLYDVYMDPDTPFPQPSISYSLHSPQTTNVTVPLSSGFDFPFSSTVPLQPGPDIVSPVAPTYTPFVPVIPTSPFNNVLVYGSDFILHPSYFLRRRRKRFPYFFADVRVAA
Organism_Source Human papillomavirus 67
Functional_Classification Viral capsid protein
Cellular_Localization Extracellular
Gene_Names L2
UniProt_ID O90729
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name HPV L2 peptide (15-36)
Peptide_Sequence ATQLYKTCKQAGTCPPDIIPKV
Peptide_Length 22
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)N)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)O)C(C)C)[C@@H](C)CC
Chemical_Modification None
Cyclization_Method Side chain-side chain cyclization; C8<->C14; disulfide bond
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2375.83
Aliphatic_Index 75.45455
Aromaticity 0.04545
Average_Rotatable_Bonds 3.36364
Charge_at_pH_7 1.87275
Isoelectric_point 8.78694
Number_of_Hydrogen_Bond_Acceptors 35
Number_of_Hydrogen_Bond_Donors 32
Topological_Polar_Surface_Area 930.51000
X_logP_energy -9.09380
Interaction Information
Affinity EC50=249000 uM
Affinity_Assay ELISA
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Patent
Title SYNTHETIC VIRUS-LIKE PARTICLES CONUGATED TO HUMAN PAPILLOMAVIRUS CAPSID PEPTIDES FOR USE AS VACCINES
Release_Year 2011
Patent_ID US20110171248A1