PPIPT00634

Target Protein Information
Protein_Name Neutrophil cytosol factor 1
Protein_Sequence MGDTFIRHIALLGFEKRFVPSQHYVYMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPIEAGAINPENRIIPHLPAPKWFDGQRAAENRQGTLTEYCSTLMSLPTKISRCPHLLDFFKVRPDDLKLPTDNQTKKPETYLMPKDGKSTATDITGPIILQTYRAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETEDPEPNYAGEPYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQKSGQDVSQAQRQIKRGAPPRRSSIRNAHSIHQRSRKRLSQDAYRRNSVRFLQQRRRQARPGPQSPGSPLEEERQTQRSKPQPAVPPRPSADLILNRCSESTKRKLASAV
Organism_Source Homo sapiens
Functional_Classification NADPH oxidase cytosolic subunit
Cellular_Localization Cytoplasm
Gene_Names NCF1
UniProt_ID P14598
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name p22 middle proline-rich peptide
Peptide_Sequence PSNPPPCASXXXXXXXXXXXXXXXXX
Peptide_Length 26
Peptide_SMILES C[C@H](NC(=O)[C@H](CS)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1838.84
Aliphatic_Index 3.84615
Aromaticity 0.00000
Average_Rotatable_Bonds 2.03846
Charge_at_pH_7 -0.06399
Isoelectric_point 5.92254
Number_of_Hydrogen_Bond_Acceptors 31
Number_of_Hydrogen_Bond_Donors 28
Topological_Polar_Surface_Area 834.01000
X_logP_energy -20.99490
Interaction Information
Affinity IC50=5.8 nM
Affinity_Assay Fluorescence Polarization
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Patent
Title METHOD FOR THE SCREENING OF COMPOUNDS THAT INHIBIT THE INTERACTION BETWEEN A PROLINE-RICH PEPTIDE AND A SH3 DOMAIN-COMPRISING PEPTIDE
Release_Year 2003
Patent_ID US20030108975A1