PPIPT00676

Target Protein Information
Protein_Name Streptavidin
Protein_Sequence MRKIVVAAIAVSLTTVSITASASADPSKDSKAQVSAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPSAASIDAAKKAGVNNGNPLDAVQQ
Organism_Source Streptomyces avidinii
Functional_Classification Biotin-binding protein
Cellular_Localization Extracellular
Gene_Names None
UniProt_ID P22629
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name SEQ ID NO:11
Peptide_Sequence EGEFCSWAPPFKASCGDPALK
Peptide_Length 21
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2240.53
Aliphatic_Index 32.85714
Aromaticity 0.14286
Average_Rotatable_Bonds 3.14286
Charge_at_pH_7 -1.12256
Isoelectric_point 4.42631
Number_of_Hydrogen_Bond_Acceptors 31
Number_of_Hydrogen_Bond_Donors 29
Topological_Polar_Surface_Area 839.14000
X_logP_energy -7.50260
Interaction Information
Affinity IC50=50 uM
Affinity_Assay radioligand displacement assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Patent
Title Method for producing filamentous phages displaying on the surface of the capsid peptides capable of binding biotin, and filamentous phages and peptides thus obtained.
Release_Year 1994
Patent_ID EP0627488A1