PPIPT00715

Target Protein Information
Protein_Name Low affinity immunoglobulin gamma Fc region receptor II-a
Protein_Sequence MTMETQMSQNVCPRNLWLLQPLTVLLLLASADSQAAAPPKAVLKLEPPWINVLQEDSVTLTCQGARSPESDSIQWFHNGNLIPTHTQPSYRFKANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQEGETIMLRCHSWKDKPLVKVTFFQNGKSQKFSHLDPTFSIPQANHSHSGDYHCTGNIGYTLFSSKPVTITVQVPSMGSSSPMGIIVAVVIATAVAAIVAAVVALIYCRKKRISANSTDPVKAAQFEPPGRQMIAIRKRQLEETNNDYETADGGYMTLNPRAPTDDDKNIYLTLPPNDHVNSNN
Organism_Source Homo sapiens
Functional_Classification Fc receptor (low-affinity IgG)
Cellular_Localization Plasma membrane
Gene_Names FCGR2A
UniProt_ID P12318
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name ShK1-35
Peptide_Sequence XXXXXXYYYYYYZZZZZZZZZZ
Peptide_Length 22
Peptide_SMILES NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)O
Chemical_Modification None
Cyclization_Method Side chain cyclization; disulfide bond
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1909.90
Aliphatic_Index 0.00000
Aromaticity 0.27273
Average_Rotatable_Bonds 2.50000
Charge_at_pH_7 -0.00712
Isoelectric_point 6.06206
Number_of_Hydrogen_Bond_Acceptors 29
Number_of_Hydrogen_Bond_Donors 29
Topological_Polar_Surface_Area 795.80000
X_logP_energy -11.62870
Interaction Information
Affinity IC50=11 nM
Affinity_Assay ELISA
PDB_ID None
Type Antagonist
Structure
Reference Information
Document_Type Patent
Title Conjugated Toxin Peptide Therapeutic Agents
Release_Year 2009
Patent_ID US20090291885A1