PPIPT00735
Target Protein Information
| Protein_Name | Beta-2-microglobulin |
|---|---|
| Protein_Sequence | MSRSVALAVLALLSLSGLEAIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM |
| Organism_Source | Homo sapiens |
| Functional_Classification | MHC class I light chain |
| Cellular_Localization | Extracellular |
| Gene_Names | B2M |
| UniProt_ID | P61769 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | 6 |
|---|---|
| Peptide_Sequence | PPPVPPPLLLLLLLL |
| Peptide_Length | 15 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1)C(C)C)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1605.12 |
|---|---|
| Aliphatic_Index | 227.33333 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 2.73333 |
| Charge_at_pH_7 | -0.00202 |
| Isoelectric_point | 6.10000 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 16 |
| Number_of_Hydrogen_Bond_Donors | 11 |
| Topological_Polar_Surface_Area | 412.78000 |
| X_logP_energy | 4.16600 |
Interaction Information
| Affinity | KD=11 nM |
|---|---|
| Affinity_Assay | ELISA |
| PDB_ID | None |
| Type | Agonist |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | NOVEL PEPTIDES AND USES THEREOF |
| Release_Year | 2013 |
| Patent_ID | US20130331297A1 |