PPIPT00757
Target Protein Information
| Protein_Name | Cysteinyl leukotriene receptor 1 |
|---|---|
| Protein_Sequence | MDETGNLTVSSATCHDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRLSTFRKHSLSSVTYVPRKKASLPEKGEEICKV |
| Organism_Source | Homo sapiens |
| Functional_Classification | G protein-coupled receptor |
| Cellular_Localization | Plasma membrane |
| Gene_Names | CYSLTR1 |
| UniProt_ID | Q9Y271 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Leukotriene C4 |
|---|---|
| Peptide_Sequence | ECG |
| Peptide_Length | 3 |
| Peptide_SMILES | N[C@@H](CCC(=O)O)C(=O)N[C@@H](CS)C(=O)NCC(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 307.32 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.00000 |
| Charge_at_pH_7 | -1.06222 |
| Isoelectric_point | 3.84996 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 6 |
| Number_of_Hydrogen_Bond_Donors | 6 |
| Topological_Polar_Surface_Area | 158.82000 |
| X_logP_energy | -2.20610 |
Interaction Information
| Affinity | KD=2.2 nM |
|---|---|
| Affinity_Assay | radioligand binding assay |
| PDB_ID | None |
| Type | Agonist |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | PEPTIDE LEUKOTRIENE RECEPTOR |
| Release_Year | 2005 |
| Patent_ID | US20050037968A1 |