PPIPT00767

Target Protein Information
Protein_Name Interleukin-8
Protein_Sequence MTSKLAVALLAAFLISAALCEGAVLPRSAKELRCQCIKTYSKPFHPKFIKELRVIESGPHCANTEIIVKLSDGRELCLDPKENWVQRVVEKFLKRAENS
Organism_Source Homo sapiens
Functional_Classification Chemokine (CXC family)
Cellular_Localization Extracellular
Gene_Names CXCL8
UniProt_ID P10145
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name CBP6
Peptide_Sequence VTTFFDYDYGAPC
Peptide_Length 13
Peptide_SMILES CC(C)[C@H](N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)O)[C@@H](C)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1498.63
Aliphatic_Index 30.00000
Aromaticity 0.30769
Average_Rotatable_Bonds 3.07692
Charge_at_pH_7 -2.06480
Isoelectric_point 3.49187
Number_of_Hydrogen_Bond_Acceptors 21
Number_of_Hydrogen_Bond_Donors 20
Topological_Polar_Surface_Area 559.25000
X_logP_energy -3.94780
Interaction Information
Affinity KD=1.06 uM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Allosteric modulator
Structure
Reference Information
Document_Type Patent
Title Pharmaceutical peptides for the treatment of inflammatory diseases
Release_Year 2010
Patent_ID US20100227824A1