PPIPT00785
Target Protein Information
| Protein_Name | Fimbrial subunit type 3 |
|---|---|
| Protein_Sequence | MKKVLLSAAMATAFFGMAAANAADTNVGGGQVNFFGKVTDVSCTVSVNGQGSDANVYLSPVTLTEVKAAAADTYLKPKSFTIDVSDCQAADGTKQDDVSKLGVNWTGGNLLAGATAKQQGYLANTEAAGAQNIQLVLSTDNATALTNKIIPGDSTQPKAAGDASAVQDGARFTYYVGYATSTPTTVTTGVVNSYATYEITYQ |
| Organism_Source | Klebsiella pneumoniae |
| Functional_Classification | Pilus assembly structural protein |
| Cellular_Localization | Extracellular |
| Gene_Names | mrkA |
| UniProt_ID | P12267 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | cy(LLFFF) |
|---|---|
| Peptide_Sequence | LLFFF |
| Peptide_Length | 5 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | Main chain-side chain cyclization; Pra1<->Z8; other bonds |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 685.86 |
|---|---|
| Aliphatic_Index | 156.00000 |
| Aromaticity | 0.60000 |
| Average_Rotatable_Bonds | 3.80000 |
| Charge_at_pH_7 | -0.00202 |
| Isoelectric_point | 6.10000 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 6 |
| Number_of_Hydrogen_Bond_Donors | 6 |
| Topological_Polar_Surface_Area | 179.72000 |
| X_logP_energy | 3.15780 |
Interaction Information
| Affinity | EC50=50 nM |
|---|---|
| Affinity_Assay | ELISA |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | EPITOPE-TARGETED PEPTIDE IMMUNOSTIMULANTS |
| Release_Year | 2020 |
| Patent_ID | US20200323973A1 |