PPIPT00806

Target Protein Information
Protein_Name Wilms tumor protein
Protein_Sequence MGSDVRDLNALLPAVPSLGGGGGCALPVSGAAQWAPVLDFAPPGASAYGSLGGPAPPPAPPPPPPPPPHSFIKQEPSWGGAEPHEEQCLSAFTVHFSGQFTGTAGACRYGPFGPPPPSQASSGQARMFPNAPYLPSCLESQPAIRNQGYSTVTFDGTPSYGHTPSHHAAQFPNHSFKHEDPMGQQGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQLECMTWNQMNLGATLKGVAAGSSSSVKWTEGQSNHSTGYESDNHTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFSRSDQLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGKTSEKPFSCRWPSCQKKFARSDELVRHHNMHQRNMTKLQLAL
Organism_Source Homo sapiens
Functional_Classification Zinc-finger transcription factor
Cellular_Localization Nucleus
Gene_Names WT1
UniProt_ID P19544
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name WT1 peptide
Peptide_Sequence RMFPNAPYL
Peptide_Length 9
Peptide_SMILES CSCC[C@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1108.32
Aliphatic_Index 54.44444
Aromaticity 0.22222
Average_Rotatable_Bonds 3.33333
Charge_at_pH_7 0.99713
Isoelectric_point 9.34881
Number_of_Hydrogen_Bond_Acceptors 14
Number_of_Hydrogen_Bond_Donors 13
Topological_Polar_Surface_Area 403.76000
X_logP_energy -1.56213
Interaction Information
Affinity KD=3.08 nM
Affinity_Assay Surface Plasmon Resonance
PDB_ID 3HPJ
Type Affinity ligand
Structure
Reference Information
Document_Type Patent
Title ANTIGEN-BINDING PROTEINS SPECIFIC FOR HLA-A2-RESTRICTED WILMS TUMOR 1 PEPTIDE
Release_Year 2016
Patent_ID US20160152725A1