PPIPT00826

Target Protein Information
Protein_Name Golgi-associated PDZ and coiled-coil motif-containing protein
Protein_Sequence MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQLVDLKSELTETQAEKVVLEKEVHDQLLQLHSIQLQLHAKTGQSADSGTIKAKLSGPSVEELERELEANKKEKMKEAQLEAEVKLLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQGFNKKAVTDTHENGDLGTASETPLDDGASKLDDLHTLYHKKSY
Organism_Source Homo sapiens
Functional_Classification Scaffold/adaptor protein (PDZ domains)
Cellular_Localization Cytoplasm
Gene_Names GOPC
UniProt_ID Q9HD26
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Peptide 8
Peptide_Sequence CRRRRFWQCTRV
Peptide_Length 12
Peptide_SMILES CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CS)[C@@H](C)O)C(=O)O
Chemical_Modification None
Cyclization_Method Side chain cyclization; C1 <-> C6; disulfide bond
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1666.99
Aliphatic_Index 24.16667
Aromaticity 0.16667
Average_Rotatable_Bonds 4.50000
Charge_at_pH_7 4.87402
Isoelectric_point 12.32409
Number_of_Hydrogen_Bond_Acceptors 22
Number_of_Hydrogen_Bond_Donors 33
Topological_Polar_Surface_Area 772.03000
X_logP_energy -7.82395
Interaction Information
Affinity KD=489 nM
Affinity_Assay Fluorescence Polarization
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Patent
Title CELL PENETRATING PEPTIDES AND METHODS OF MAKING AND USING THEREOF
Release_Year 2020
Patent_ID US20200385427A1