PPIPT00843

Target Protein Information
Protein_Name Type IV major pilin protein PilA
Protein_Sequence MKAQKGFTLIELMIVVAIIGILAAIAIPQYQNYVARSEGASALATINPLKTTVEESLSRGIAGSKIKIGTTASTATETYVGVEPDANKLGVIAVAIEDSGAGDITFTFQTGTSSPKNATKVITLNRTADGVWACKSTQDPMFTPKGCDN
Organism_Source Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Functional_Classification Pilus structural subunit
Cellular_Localization Extracellular
Gene_Names pilA
UniProt_ID P04739
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name KB7 peptide
Peptide_Sequence SCATTWDAKFRPNGCTD
Peptide_Length 17
Peptide_SMILES C[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CS)NC(=O)[C@@H](N)CO)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method Side chain-side chain cyclization; C2<->C15; disulfide bond
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1873.04
Aliphatic_Index 11.76471
Aromaticity 0.11765
Average_Rotatable_Bonds 3.29412
Charge_at_pH_7 -0.12537
Isoelectric_point 6.17547
Number_of_Hydrogen_Bond_Acceptors 29
Number_of_Hydrogen_Bond_Donors 31
Topological_Polar_Surface_Area 822.45000
X_logP_energy -11.48943
Interaction Information
Affinity IC50=704 uM
Affinity_Assay ELISA
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Patent
Title PEPTIDE COMPOSITIONS AND METHODS OF PRODUCING AND USING SAME
Release_Year 2003
Patent_ID US20030228324A1