PPIPT00868
Target Protein Information
| Protein_Name | Melanoma-associated antigen 4 |
|---|---|
| Protein_Sequence | MSSEQKSQHCKPEEGVEAQEEALGLVGAQAPTTEEQEAAVSSSSPLVPGTLEEVPAAESAGPPQSPQGASALPTTISFTCWRQPNEGSSSQEEEGPSTSPDAESLFREALSNKVDELAHFLLRKYRAKELVTKAEMLERVIKNYKRCFPVIFGKASESLKMIFGIDVKEVDPASNTYTLVTCLGLSYDGLLGNNQIFPKTGLLIIVLGTIAMEGDSASEEEIWEELGVMGVYDGREHTVYGEPRKLLTQDWVQENYLEYRQVPGSNPARYEFLWGPRALAETSYVKVLEHVVRVNARVRIAYPSLREAALLEEEEGV |
| Organism_Source | Homo sapiens |
| Functional_Classification | Cancer/testis antigen |
| Cellular_Localization | Nucleus |
| Gene_Names | MAGEA4 |
| UniProt_ID | P43358 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | MAGE-A4 p230-239 |
|---|---|
| Peptide_Sequence | GVYDGREHTV |
| Peptide_Length | 10 |
| Peptide_SMILES | CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CN)C(C)C)[C@@H](C)O)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
|
|
|
Peptide Physicochemical
| Molecular_Weight | 1132.20 |
|---|---|
| Aliphatic_Index | 58.00000 |
| Aromaticity | 0.10000 |
| Average_Rotatable_Bonds | 3.50000 |
| Charge_at_pH_7 | -0.90974 |
| Isoelectric_point | 5.45425 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 17 |
| Number_of_Hydrogen_Bond_Donors | 19 |
| Topological_Polar_Surface_Area | 530.86000 |
| X_logP_energy | -5.76603 |
Interaction Information
| Affinity | KD=22 nM |
|---|---|
| Affinity_Assay | Surface Plasmon Resonance |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | ANTIGEN-BINDING PROTEIN THAT RECOGNIZES MAGE-A4-DERIVED PEPTIDE |
| Release_Year | 2020 |
| Patent_ID | US20200276237A1 |