PPIPT00993
Target Protein Information
| Protein_Name | LexA repressor |
|---|---|
| Protein_Sequence | MKALTARQQEVFDLIRDHISQTGMPPTRAEIAQRLGFRSPNAAEEHLKALARKGVIEIVSGASRGIRLLQEEEEGLPLVGRVAAGEPLLAQQHIEGHYQVDPSLFKPNADFLLRVSGMSMKDIGIMDGDLLAVHKTQDVRNGQVVVARIDDEVTVKRLKKQGNKVELLPENSEFKPIVVDLRQQSFTIEGLAVGVIRNGDWL |
| Organism_Source | Escherichia coli (strain SE11) |
| Functional_Classification | Helixurnelix transcriptional repressor |
| Cellular_Localization | Cytoplasm |
| Gene_Names | lexA |
| UniProt_ID | B6I5Q8 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | L2 |
|---|---|
| Peptide_Sequence | SRSWDLPGEY |
| Peptide_Length | 10 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CO)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
|
|
|
Peptide Physicochemical
| Molecular_Weight | 1209.28 |
|---|---|
| Aliphatic_Index | 39.00000 |
| Aromaticity | 0.20000 |
| Average_Rotatable_Bonds | 3.50000 |
| Charge_at_pH_7 | -1.00065 |
| Isoelectric_point | 4.18441 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 17 |
| Number_of_Hydrogen_Bond_Donors | 19 |
| Topological_Polar_Surface_Area | 529.41000 |
| X_logP_energy | -4.79513 |
Interaction Information
| Affinity | KD=1.7 uM |
|---|---|
| Affinity_Assay | Surface Plasmon Resonance |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | STABILIZATION OF CYCLIC PEPTIDE STRUCTURES |
| Release_Year | 2010 |
| Patent_ID | US20100129807A1 |