PPIPT00996

Target Protein Information
Protein_Name GTPase HRas
Protein_Sequence MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPGCMSCKCVLS
Organism_Source Homo sapiens
Functional_Classification Small GTPase (Ras family)
Cellular_Localization Plasma membrane
Gene_Names HRAS
UniProt_ID P01112
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name GAP888-910(Gly903)
Peptide_Sequence MTRRVVSGFVFLRLIGPAILNPR
Peptide_Length 23
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@@H](N)CCSC)[C@@H](C)O)C(C)C)C(C)C)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2613.21
Aliphatic_Index 126.95652
Aromaticity 0.08696
Average_Rotatable_Bonds 3.60870
Charge_at_pH_7 3.99797
Isoelectric_point 12.97715
Number_of_Hydrogen_Bond_Acceptors 32
Number_of_Hydrogen_Bond_Donors 37
Topological_Polar_Surface_Area 1017.09000
X_logP_energy -6.90242
Interaction Information
Affinity IC50=180 uM
Affinity_Assay Enzyme Inhibition Kinetics
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Patent
Title Peptide inhibitors of RAS-GAP interaction
Release_Year 1992
Patent_ID 0496162A2