PPIPT01005

Target Protein Information
Protein_Name GTPase HRas
Protein_Sequence MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPGCMSCKCVLS
Organism_Source Homo sapiens
Functional_Classification Small GTPase (Ras family)
Cellular_Localization Plasma membrane
Gene_Names HRAS
UniProt_ID P01112
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Ras21-32
Peptide_Sequence IQLIQNHFVDEY
Peptide_Length 12
Peptide_SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(C)C)[C@@H](C)CC
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1518.69
Aliphatic_Index 121.66667
Aromaticity 0.16667
Average_Rotatable_Bonds 4.08333
Charge_at_pH_7 -1.90974
Isoelectric_point 4.18115
Number_of_Hydrogen_Bond_Acceptors 20
Number_of_Hydrogen_Bond_Donors 20
Topological_Polar_Surface_Area 636.20000
X_logP_energy -3.57190
Interaction Information
Affinity IC50=70 uM
Affinity_Assay Enzyme Inhibition Kinetics
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Patent
Title Peptide inhibitors of RAS-GAP interaction
Release_Year 1992
Patent_ID 0496162A2