PPIPT01006
Target Protein Information
| Protein_Name | GTPase HRas |
|---|---|
| Protein_Sequence | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPGCMSCKCVLS |
| Organism_Source | Homo sapiens |
| Functional_Classification | Small GTPase (Ras family) |
| Cellular_Localization | Plasma membrane |
| Gene_Names | HRAS |
| UniProt_ID | P01112 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Ras26-32 |
|---|---|
| Peptide_Sequence | NHFVDEY |
| Peptide_Length | 7 |
| Peptide_SMILES | CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](N)CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 922.95 |
|---|---|
| Aliphatic_Index | 41.42857 |
| Aromaticity | 0.28571 |
| Average_Rotatable_Bonds | 3.85714 |
| Charge_at_pH_7 | -1.90974 |
| Isoelectric_point | 4.18115 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 13 |
| Number_of_Hydrogen_Bond_Donors | 13 |
| Topological_Polar_Surface_Area | 404.52000 |
| X_logP_energy | -2.66520 |
Interaction Information
| Affinity | IC50=350 uM |
|---|---|
| Affinity_Assay | Enzyme Inhibition Kinetics |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | Peptide inhibitors of RAS-GAP interaction |
| Release_Year | 1992 |
| Patent_ID | 0496162A2 |