PPIPT01007
Target Protein Information
| Protein_Name | GTPase HRas |
|---|---|
| Protein_Sequence | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPGCMSCKCVLS |
| Organism_Source | Homo sapiens |
| Functional_Classification | Small GTPase (Ras family) |
| Cellular_Localization | Plasma membrane |
| Gene_Names | HRAS |
| UniProt_ID | P01112 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Ras19-32(D-Asn) |
|---|---|
| Peptide_Sequence | LTIQLIQnHFVDEY |
| Peptide_Length | 14 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CC(C)C)[C@@H](C)O)[C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(C)C |
| Chemical_Modification | a26=D-Asn |
| Cyclization_Method | None |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1732.95 |
|---|---|
| Aliphatic_Index | 132.14286 |
| Aromaticity | 0.14286 |
| Average_Rotatable_Bonds | 4.00000 |
| Charge_at_pH_7 | -1.90974 |
| Isoelectric_point | 4.18115 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 23 |
| Number_of_Hydrogen_Bond_Donors | 23 |
| Topological_Polar_Surface_Area | 714.63000 |
| X_logP_energy | -4.17540 |
Interaction Information
| Affinity | IC50=0.2 uM |
|---|---|
| Affinity_Assay | Enzyme Inhibition Kinetics |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | Peptide inhibitors of RAS-GAP interaction |
| Release_Year | 1992 |
| Patent_ID | 0496162A2 |