PPIPT01022

Target Protein Information
Protein_Name Metastasis-suppressor KiSS-1
Protein_Sequence MNSLVSWQLLLFLCATHFGEPLEKVASVGNSRPTGQQLESLGLLAPGEQSLPCTERKPAATARLSRRGTSLSPPPESSGSPQQPGLSAPHSRQIPAPQGAVLVQREKDLPNYNWNSFGLRFGKREAAPGNHGRSAGRG
Organism_Source Homo sapiens
Functional_Classification Secreted metastasis-suppressor peptide
Cellular_Localization Extracellular
Gene_Names KISS1
UniProt_ID Q15726
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name biotinyl-PrP106-126
Peptide_Sequence TNMKHMAGAAAAGAVVGGLGGG
Peptide_Length 22
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)NCC(=O)O)C(C)C)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Cyclic
N-terminal_Modification biotinyl
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1898.19
Aliphatic_Index 71.36364
Aromaticity 0.00000
Average_Rotatable_Bonds 2.81818
Charge_at_pH_7 1.08860
Isoelectric_point 9.70200
Number_of_Hydrogen_Bond_Acceptors 29
Number_of_Hydrogen_Bond_Donors 27
Topological_Polar_Surface_Area 792.44000
X_logP_energy -11.66640
Interaction Information
Affinity KD=34.2 nM
Affinity_Assay ELISA
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Patent
Title Kisspeptin peptides for use in the treatment of Alzheimer's disease, Creutzfeldt-Jakob disease or diabetes mellitus
Release_Year 2011
Patent_ID EP2388012A1