PPIPT01058

Target Protein Information
Protein_Name Delta-type opioid receptor
Protein_Sequence MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
Organism_Source Homo sapiens
Functional_Classification GPCR (u-opioid receptor)
Cellular_Localization Plasma membrane
Gene_Names OPRD1
UniProt_ID P41143
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Control
Peptide_Sequence RVFSLCNATYPYKGACPT
Peptide_Length 18
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method Side chain-side chain cyclization; C6<->C16; disulfide bond
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1991.31
Aliphatic_Index 48.88889
Aromaticity 0.16667
Average_Rotatable_Bonds 3.16667
Charge_at_pH_7 1.87204
Isoelectric_point 8.77185
Number_of_Hydrogen_Bond_Acceptors 29
Number_of_Hydrogen_Bond_Donors 29
Topological_Polar_Surface_Area 772.60000
X_logP_energy -7.95393
Interaction Information
Affinity KD=26 nM
Affinity_Assay protein binding radioassay
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Patent
Title CYCLIC PEPTIDES, CYCLIC PEPTIDE CONJUGATES AND METHODS OF USE THEREOF
Release_Year 2019
Patent_ID US20190300571A1