PPIPT01064

Target Protein Information
Protein_Name Kappa-type opioid receptor
Protein_Sequence MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
Organism_Source Homo sapiens
Functional_Classification GPCR (u-opioid receptor)
Cellular_Localization Plasma membrane
Gene_Names OPRK1
UniProt_ID P41145
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name DADLE-OL
Peptide_Sequence YASPKCFRYaGFlLACT
Peptide_Length 17
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CS)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method Side chain-side chain cyclization; C6<->C16; disulfide bond
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1911.27
Aliphatic_Index 63.52941
Aromaticity 0.23529
Average_Rotatable_Bonds 3.29412
Charge_at_pH_7 1.87204
Isoelectric_point 8.77185
Number_of_Hydrogen_Bond_Acceptors 26
Number_of_Hydrogen_Bond_Donors 27
Topological_Polar_Surface_Area 688.97000
X_logP_energy -4.54843
Interaction Information
Affinity KD=1082 nM
Affinity_Assay protein binding radioassay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Patent
Title CYCLIC PEPTIDES, CYCLIC PEPTIDE CONJUGATES AND METHODS OF USE THEREOF
Release_Year 2019
Patent_ID US20190300571A1