PPIPT01101

Target Protein Information
Protein_Name Lupus La protein
Protein_Sequence MAENGDNEKMAALEAKICHQIEYYFGDFNLPRDKFLKEQIKLDEGWVPLEIMIKFNRLNRLTTDFNVIVEALSKSKAELMEISEDKTKIRRSPSKPLPEVTDEYKNDVKNRSVYIKGFPTDATLDDIKEWLEDKGQVLNIQMRRTLHKAFKGSIFVVFDSIESAKKFVETPGQKYKETDLLILFKDDYFAKKNEERKQNKVEAKLRAKQEQEAKQKLEEDAEMKSLEEKIGCLLKFSGDLDDQTCREDLHILFSNHGEIKWIDFVRGAKEGIILFKEKAKEALGKAKDANNGNLQLRNKEVTWEVLEGEVEKEALKKIIEDQQESLNKWKSKGRRFKGKGKGNKAAQPGSGKGKVQFQGKKTKFASDDEHDEHDENGATGPVKRAREETDKEEPASKQQKTENGAGDQ
Organism_Source Homo sapiens
Functional_Classification RNA-binding protein (La antigen)
Cellular_Localization Cytoplasm
Gene_Names SSB
UniProt_ID P05455
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name LaR2C
Peptide_Sequence KYKETDLLILFKDDYFAKKNEERK
Peptide_Length 24
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CCCCN)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 3035.49
Aliphatic_Index 69.16667
Aromaticity 0.16667
Average_Rotatable_Bonds 4.54167
Charge_at_pH_7 1.00117
Isoelectric_point 9.04328
Number_of_Hydrogen_Bond_Acceptors 42
Number_of_Hydrogen_Bond_Donors 44
Topological_Polar_Surface_Area 1278.22000
X_logP_energy -7.55303
Interaction Information
Affinity IC50=30 uM
Affinity_Assay in vitro translation assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Patent
Title SMALLANTIVIRAL PEPTIDES AGAINST HEPATITIS CVIRUS
Release_Year 2009
Patent_ID US20090233868A1