PPIPT01124

Target Protein Information
Protein_Name Serine/threonine-protein kinase PLK1
Protein_Sequence MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS
Organism_Source Homo sapiens
Functional_Classification Serine/threonine kinase
Cellular_Localization Cytoplasm
Gene_Names PLK1
UniProt_ID P53350
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name LHSpTA
Peptide_Sequence LHSTA
Peptide_Length 5
Peptide_SMILES CC(C)C[C@H](N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)O)[C@@H](C)O
Chemical_Modification T4=phosphothreonine
Cyclization_Method None
Linear/Cyclic Cyclic
N-terminal_Modification Acetyl
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 527.58
Aliphatic_Index 98.00000
Aromaticity 0.00000
Average_Rotatable_Bonds 3.00000
Charge_at_pH_7 0.08889
Isoelectric_point 7.55032
Number_of_Hydrogen_Bond_Acceptors 9
Number_of_Hydrogen_Bond_Donors 9
Topological_Polar_Surface_Area 248.86000
X_logP_energy -3.25760
Interaction Information
Affinity KD=0.447 uM
Affinity_Assay Isothermal Titration Calorimetry
PDB_ID 3FVH
Type Antagonist
Structure
Reference Information
Document_Type Patent
Title PEPTIDE MIMETIC LIGANDS OF POLO-LIKE KINASE 1 POLO BOX DOMAIN AND METHODS OF USE
Release_Year 2012
Patent_ID US20120065146A1