PPIPT01186
Target Protein Information
| Protein_Name | Telomerase reverse transcriptase |
|---|---|
| Protein_Sequence | MPRAPRCRAVRSLLRSHYREVLPLATFVRRLGPQGWRLVQRGDPAAFRALVAQCLVCVPWDARPPPAAPSFRQVSCLKELVARVLQRLCERGAKNVLAFGFALLDGARGGPPEAFTTSVRSYLPNTVTDALRGSGAWGLLLRRVGDDVLVHLLARCALFVLVAPSCAYQVCGPPLYQLGAATQARPPPHASGPRRRLGCERAWNHSVREAGVPLGLPAPGARRRGGSASRSLPLPKRPRRGAAPEPERTPVGQGSWAHPGRTRGPSDRGFCVVSPARPAEEATSLEGALSGTRHSHPSVGRQHHAGPPSTSRPPRPWDTPCPPVYAETKHFLYSSGDKEQLRPSFLLSSLRPILTGARRLVETIFLGSSPGCQGLPAGCPACPSATGKCGPCFWSCLGTTRSAPTGCSSRRTARCELRSPQQPVSVPGRSPRALWRPPRRRTQTPVAWCSCSASTAPLAGVRLRAGLPAPAGAPRPLGLQAQRRRFLRNTKKFISLGKHAKLSLQELTWKMSVRDCAWLRRSP |
| Organism_Source | Homo sapiens |
| Functional_Classification | Reverse transcriptase (telomerase) |
| Cellular_Localization | Nucleus |
| Gene_Names | hTERT |
| UniProt_ID | O94807 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | T865 |
|---|---|
| Peptide_Sequence | RLVDDFLLV |
| Peptide_Length | 9 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)O)C(C)C |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1089.30 |
|---|---|
| Aliphatic_Index | 194.44444 |
| Aromaticity | 0.11111 |
| Average_Rotatable_Bonds | 3.88889 |
| Charge_at_pH_7 | -1.00113 |
| Isoelectric_point | 4.10925 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 13 |
| Number_of_Hydrogen_Bond_Donors | 15 |
| Topological_Polar_Surface_Area | 432.62000 |
| X_logP_energy | -0.81763 |
Interaction Information
| Affinity | KD=10 nM |
|---|---|
| Affinity_Assay | Competitive binding assay |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | MHC-PEPTIDE_COMPLEX_BINDING_LIGANDS |
| Release_Year | 2003 |
| Patent_ID | US20030223994A1 |