PPIPT01211

Target Protein Information
Protein_Name Serine/threonine-protein kinase PLK1
Protein_Sequence MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS
Organism_Source Homo sapiens
Functional_Classification Serine/threonine kinase
Cellular_Localization Cytoplasm
Gene_Names PLK1
UniProt_ID P53350
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name 1010pT peptide
Peptide_Sequence GVLSTLI
Peptide_Length 7
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)CN)C(C)C)[C@@H](C)O)C(=O)O
Chemical_Modification T5=phosphothreonine
Cyclization_Method None
Linear/Cyclic Cyclic
N-terminal_Modification FITC
C-terminal_Modification Amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 701.86
Aliphatic_Index 208.57143
Aromaticity 0.00000
Average_Rotatable_Bonds 3.14286
Charge_at_pH_7 -0.00202
Isoelectric_point 6.10000
Number_of_Hydrogen_Bond_Acceptors 10
Number_of_Hydrogen_Bond_Donors 10
Topological_Polar_Surface_Area 278.38000
X_logP_energy -1.89410
Interaction Information
Affinity KD=69.91 nM
Affinity_Assay Fluorescence Polarization
PDB_ID 4O9W
Type Inhibitor
Structure
Reference Information
Document_Type Patent
Title PEPTIDES DERIVED FROM NCAPG2 AND THEIR USE
Release_Year 2016
Patent_ID US20160347801A1