PPIPT01317

Target Protein Information
Protein_Name Ig gamma-1 chain C region
Protein_Sequence AETTAPSVYPLAPGTALKSNSMVTLGCLVKGYFPEPVTVTWNSGALSSGVHTFPAVLQSGLYTLTSSVTVPSSTWPSQTVTCNVAHPASSTKVDKKIVPRNCGGDCKPCICTGSEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISQDDPEVHFSWFVDDVEVHTAQTRPPEEQFNSTFRSVSELPILHQDWLNGRTFRCKVTSAAFPSPIEKTISKPEGRTQVPHVYTMSPTKEEMTQNEVSITCMVKGFYPPDIYVEWQMNGQPQENYKNTPPTMDTDGSYFLYSKLNVKKEKWQQGNTFTCSVLHEGLHNHHTEKSLSHSPGK
Organism_Source Rattus norvegicus
Functional_Classification IgG heavy chain constant region
Cellular_Localization Extracellular
Gene_Names None
UniProt_ID P20759
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name eTEV peptide
Peptide_Sequence RENLYFQGKDG
Peptide_Length 11
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1326.43
Aliphatic_Index 35.45455
Aromaticity 0.18182
Average_Rotatable_Bonds 4.09091
Charge_at_pH_7 -0.00094
Isoelectric_point 6.48752
Number_of_Hydrogen_Bond_Acceptors 19
Number_of_Hydrogen_Bond_Donors 21
Topological_Polar_Surface_Area 623.25000
X_logP_energy -6.38113
Interaction Information
Affinity KD=40 nM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Patent
Title TAG PEPTIDE HAVING PROTEASE RECOGNITION SEQUENCE AND UTILIZATION OF SAME
Release_Year 2012
Patent_ID EP2423218A1