PPIPT01339
Target Protein Information
| Protein_Name | Urokinase plasminogen activator surface receptor |
|---|---|
| Protein_Sequence | MGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSGRAVTYSRSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRPKDDRHLRGCGYLPGCPGSNGFHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHEPKNQSYMVRGCATASMCQHAHLGDAFSMNHIDVSCCTKSGCNHPDLDVQYRSGAAPQPGPAHLSLTITLLMTARLWGGTLLWT |
| Organism_Source | Homo sapiens |
| Functional_Classification | GPI-anchored receptor |
| Cellular_Localization | Plasma membrane |
| Gene_Names | PLAUR |
| UniProt_ID | Q03405 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | AE348 |
|---|---|
| Peptide_Sequence | EXXFsrYLWS |
| Peptide_Length | 10 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CO)C(=O)O |
| Chemical_Modification | X2=2-(2-aminoethoxy)ethoxyacetic acid; X3=cyclohexylalanine |
| Cyclization_Method | None |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1201.30 |
|---|---|
| Aliphatic_Index | 39.00000 |
| Aromaticity | 0.30000 |
| Average_Rotatable_Bonds | 3.60000 |
| Charge_at_pH_7 | -0.00109 |
| Isoelectric_point | 6.40331 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 16 |
| Number_of_Hydrogen_Bond_Donors | 19 |
| Topological_Polar_Surface_Area | 500.90000 |
| X_logP_energy | -3.90193 |
Interaction Information
| Affinity | IC50=6.7 nM |
|---|---|
| Affinity_Assay | Surface Plasmon Resonance |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | UPAR TARGETING PEPTIDE FOR USE IN PEROPERATIVE OPTICAL IMAGING OF INVASIVE CANCER |
| Release_Year | 2021 |
| Patent_ID | US20210138090A1 |