PPIPT01342

Target Protein Information
Protein_Name Urokinase plasminogen activator surface receptor
Protein_Sequence MGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSGRAVTYSRSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRPKDDRHLRGCGYLPGCPGSNGFHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHEPKNQSYMVRGCATASMCQHAHLGDAFSMNHIDVSCCTKSGCNHPDLDVQYRSGAAPQPGPAHLSLTITLLMTARLWGGTLLWT
Organism_Source Homo sapiens
Functional_Classification GPI-anchored receptor
Cellular_Localization Plasma membrane
Gene_Names PLAUR
UniProt_ID Q03405
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name IRDye800CW-AE344
Peptide_Sequence IRXDCWEEXXXFsrYLWS
Peptide_Length 18
Peptide_SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CO)C(=O)O
Chemical_Modification X3=2-(2-aminoethoxy)ethoxyacetic acid; X4=2-(2-aminoethoxy)ethoxyacetic acid; X5=cyclohexylalanine
Cyclization_Method None
Linear/Cyclic Cyclic
N-terminal_Modification IRDye800CW
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2118.31
Aliphatic_Index 43.33333
Aromaticity 0.22222
Average_Rotatable_Bonds 3.66667
Charge_at_pH_7 -1.06085
Isoelectric_point 4.42636
Number_of_Hydrogen_Bond_Acceptors 28
Number_of_Hydrogen_Bond_Donors 34
Topological_Polar_Surface_Area 885.99000
X_logP_energy -7.45806
Interaction Information
Affinity IC50=20 nM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Patent
Title UPAR TARGETING PEPTIDE FOR USE IN PEROPERATIVE OPTICAL IMAGING OF INVASIVE CANCER
Release_Year 2021
Patent_ID US20210138090A1