PPIPT01355
Target Protein Information
| Protein_Name | Voltage-gated sodium channel NaN |
|---|---|
| Protein_Sequence | LPLRTFRVFRALKAISVVS |
| Organism_Source | Homo sapiens |
| Functional_Classification | Voltage-gated sodium channel NaN |
| Cellular_Localization | Extracellular |
| Gene_Names | SCN11A |
| UniProt_ID | Q9UKU5 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | HBP08 |
|---|---|
| Peptide_Sequence | GYHYERWIH |
| Peptide_Length | 9 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CN)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | HMGB1 |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1260.38 |
|---|---|
| Aliphatic_Index | 43.33333 |
| Aromaticity | 0.33333 |
| Average_Rotatable_Bonds | 4.00000 |
| Charge_at_pH_7 | 0.17987 |
| Isoelectric_point | 7.69855 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 16 |
| Number_of_Hydrogen_Bond_Donors | 19 |
| Topological_Polar_Surface_Area | 508.93000 |
| X_logP_energy | -1.36553 |
Interaction Information
| Affinity | KD=0.79 uM |
|---|---|
| Affinity_Assay | MicroScale Thermophoresis |
| PDB_ID | 2YRQ |
| Type | Antagonist |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | PEPTIDE INHIBITORS TARGETING THE CXCL12/HMGB1 INTERACTION AND USES THEREOF |
| Release_Year | 2022 |
| Patent_ID | US20220153792A1 |