PPIPT01380
Target Protein Information
| Protein_Name | Protein Nef |
|---|---|
| Protein_Sequence | MGKIWSKSSLVGWPEIRERMRRQTQEPAVEPAVGAGAASQDLANRGAITIRNTRDNNESIAWLEAQEEEEEVGFPVRPQVPLRPITYKQAFDLSFFLKDKGGLEGLVWSRKRQDILDLWMYHTQGILPDWHNYTPGPGIRYPVTFGWCFKLVPLSAEEVEEANEGDNNALLHPICQHGADDDHKEVLVWRFDSSLARRHVARELHPEFYKNC |
| Organism_Source | Human immunodeficiency virus type 1 group N (isolate YBF30) |
| Functional_Classification | Viral accessory protein |
| Cellular_Localization | Cytoplasm |
| Gene_Names | nef |
| UniProt_ID | O91087 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | SEQID4 |
|---|---|
| Peptide_Sequence | YRWPAWLPLW |
| Peptide_Length | 10 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Amide |
| Amino_Acid_Distribution | |
|
|
|
Peptide Physicochemical
| Molecular_Weight | 1387.65 |
|---|---|
| Aliphatic_Index | 88.00000 |
| Aromaticity | 0.40000 |
| Average_Rotatable_Bonds | 3.30000 |
| Charge_at_pH_7 | 0.99713 |
| Isoelectric_point | 9.34881 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 13 |
| Number_of_Hydrogen_Bond_Donors | 16 |
| Topological_Polar_Surface_Area | 437.14000 |
| X_logP_energy | 3.26957 |
Interaction Information
| Affinity | IC50=1 uM |
|---|---|
| Affinity_Assay | ELISA |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | NOVEL PEPTIDES AND THE BIOLOGICAL USE THEREOF |
| Release_Year | 2009 |
| Patent_ID | US20090163410A1 |