PPIPT01408

Target Protein Information
Protein_Name Cytoplasmic protein NCK2
Protein_Sequence MTEEVIVIAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKNSLKKGSLVKNLKDTLGLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVKFAYVAEREDELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYVLEEVDEAAAESPSFLSLRKGASLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYVVVLSDGPALHPAHAPQISYTGPSSSGRFAGREWYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSVSLKASGKNKHFKVQLVDNVYCIGQRRFHTMDELVEHYKKAPIFTSEHGEKLYLVRALQ
Organism_Source Homo sapiens
Functional_Classification Adaptor protein (SH3 domain)
Cellular_Localization Cytoplasm
Gene_Names NCK2
UniProt_ID O43639
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Nogo-A(171-181)
Peptide_Sequence STPAAPKRRGS
Peptide_Length 11
Peptide_SMILES C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](N)CO)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CO)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1127.27
Aliphatic_Index 18.18182
Aromaticity 0.00000
Average_Rotatable_Bonds 3.09091
Charge_at_pH_7 2.99768
Isoelectric_point 12.51648
Number_of_Hydrogen_Bond_Acceptors 18
Number_of_Hydrogen_Bond_Donors 20
Topological_Polar_Surface_Area 547.25000
X_logP_energy -9.04916
Interaction Information
Affinity KD=2.8 uM
Affinity_Assay Isothermal Titration Calorimetry
PDB_ID None
Type Antagonist
Structure
Reference Information
Document_Type Patent
Title NEURONAL NETWORK-INTERACTING PEPTIDE
Release_Year 2009
Patent_ID US20090137484A1