PPIPT01421

Target Protein Information
Protein_Name Bone morphogenetic protein 2
Protein_Sequence MVAGTRCLLALLLPQVLLGGAAGLVPELGRRKFAAASSGRPSSQPSDEVLSEFELRLLSMFGLKQRPTPSRDAVVPPYMLDLYRRHSGQPGSPAPDHRLERAASRANTVRSFHHEESLEELPETSGKTTRRFFFNLSSIPTEEFITSAELQVFREQMQDALGNNSSFHHRINIYEIIKPATANSKFPVTRLLDTRLVNQNASRWESFDVTPAVMRWTAQGHANHGFVVEVAHLEEKQGVSKRHVRISRSLHQDEHSWSQIRPLLVTFGHDGKGHPLHKREKRQAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR
Organism_Source Homo sapiens
Functional_Classification TGF-u family growth factor
Cellular_Localization Extracellular
Gene_Names BMP2
UniProt_ID P12643
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name BMP Binding Peptide (BBP)
Peptide_Sequence VRCSTVRMSAEQVQNVWCR
Peptide_Length 19
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)C(C)C)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C)C(C)C
Chemical_Modification None
Cyclization_Method side chain-side chain cyclization; C3<->C18; disulfide bond
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2252.61
Aliphatic_Index 66.31579
Aromaticity 0.05263
Average_Rotatable_Bonds 3.89474
Charge_at_pH_7 1.87580
Isoelectric_point 8.83479
Number_of_Hydrogen_Bond_Acceptors 33
Number_of_Hydrogen_Bond_Donors 39
Topological_Polar_Surface_Area 1015.87000
X_logP_energy -12.46829
Interaction Information
Affinity KD=3 uM
Affinity_Assay Surface Plasmon Resonance
PDB_ID None
Type Allosteric modulator
Structure
Reference Information
Document_Type Patent
Title BONE MORPHOGENIC PROTEIN BINDING PEPTIDE
Release_Year 2015
Patent_ID US20150056700A1