PPIPT01440
Target Protein Information
| Protein_Name | Apolipoprotein A-II |
|---|---|
| Protein_Sequence | MKLLAATVLLLTICSLEGALVRRQAKEPCVESLVSQYFQTVTDYGKDLMEKVKSPELQAEAKSYFEKSKEQLTPLIKKAGTELVNFLSYFVELGTQPATQ |
| Organism_Source | Homo sapiens |
| Functional_Classification | Lipoprotein component |
| Cellular_Localization | Extracellular |
| Gene_Names | APOA2 |
| UniProt_ID | P02652 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | ApoAII-P1 |
|---|---|
| Peptide_Sequence | GYSIFSYA |
| Peptide_Length | 8 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 906.99 |
|---|---|
| Aliphatic_Index | 61.25000 |
| Aromaticity | 0.37500 |
| Average_Rotatable_Bonds | 3.12500 |
| Charge_at_pH_7 | -0.00372 |
| Isoelectric_point | 6.08660 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 13 |
| Number_of_Hydrogen_Bond_Donors | 13 |
| Topological_Polar_Surface_Area | 347.94000 |
| X_logP_energy | -2.38680 |
Interaction Information
| Affinity | KD=200 nM |
|---|---|
| Affinity_Assay | Surface Plasmon Resonance |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Patent |
|---|---|
| Title | SMALL MOLECULE AND PEPTIDE ARRAYS AND USES THEREOF |
| Release_Year | 2005 |
| Patent_ID | US20050255491A1 |